Circadian behavior of mice deficient in PER1/PML or PER2/PML

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چکیده

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Circadian behavior of mice deficient in PER1/PML or PER2/PML

BACKGROUND Our recent studies demonstrate that the murine homolog of the human tumor suppressor promyelocytic leukemia (PML) regulates circadian behavior of mice. To further gather insight into PML's contribution to circadian behavior, we generated two strains of mice deficient in one of the two period (Per) genes and the PML gene, with Per1-/-/Pml-/- and Per2-/-/Pml-/- genotypes. RESULTS Her...

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Neuroglobin (Ngb), a neuron-specific oxygen-binding globin with an unknown function, has been proposed to play a key role in neuronal survival. We have previously shown Ngb to be highly expressed in the rat suprachiasmatic nucleus (SCN). The present study addresses the effect of Ngb deficiency on circadian behavior. Ngb-deficient and wild-type (wt) mice were placed in running wheels and their a...

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ژورنال

عنوان ژورنال: Journal of Circadian Rhythms

سال: 2013

ISSN: 1740-3391

DOI: 10.1186/1740-3391-11-9